Issue: Vojnosanit Pregl 2017; Vol. 74 (No. 4)

Autoimmune pancreatitis type 1 and type 2: A report on two cases

Authors:
Irina Brčerević, Radoje Doder, Nenad Perišić, Stanko Petrović, Jasna Jović, Dejan Hristović, Zoran Djordjević, Olga Tasić Radić

Download full articele PDF

Introduction. Autoimmune pancreatitis is a disease associated
with autoimmune mechanisms, clinically manifested mostly as
obstructive icterus with or with no entire or partial enlargement
of the pancreas, histological lymphoplas-mocytic infiltration,
fibrosis or granulocytic epithelial lesions with a favourable
therapeutic response to the application of corticosteroids. Type
1 autoimmune pancreatitis is a systemic disease befalling the
group of IgG4-related diseases in contrast to type 2 which is
specific for pancreas disease. Case report. We presented two
cases. The first one was a 64-year-old male patient with
autoimmune pancreatitis complaining of abdominal pain,
weight loss, weakness and exhaustion. Clinical examination
showed a rare IgG4 autoimmune pancreatitis. The second one
was a 37-year-old male patient complaining of abdominal pain
with diarrhea. The diagnosis made revealed the presence of
type 2 autoimmune pancreatitis. Following the diagnosis,
immunosuppressive therapy was administered to both patients
leading to the improvement of their general condition.
Conclusion. Autoimmune pancreatitis is a rare disease,
sometimes not easy to differ from pancreatic tumor or bile
duct tumor with poor prognosis. Thus, early recognition of the
disease is very important, since adequate treatment significantly
increases the course and the outcomes of the disease.