Issue: Vojnosanit Pregl 2017; Vol. 74 (No. 3)
Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease
Authors:
Violeta Kolarov, Biljana Zvezdin, Mirna Djurić, Mirjana Hadnadjev, Sanja Hromiš, Katarina Nikoletić, Bojana Trivić
Background/Aim. Infection is the major cause of acuteexacerbation of chronic obstructive pulmonary disease (AECOPD).
The aim of the study was to establish the most common
bacterial agents of AE-COPD in patients hospitalized in a tertiary
medical care institution. Methods. This retrospective study included
the patients hospitalized due to infective AE-COPD in the Institute
for Pulmonary Diseases of Vojvodina, Sremska Kamenica
in a 12-month period. We evaluated clinical data, spirometry, pathogen
etiology in the patients with positive sputum findings and
disease outcome. Results. The study included a total of 81 patients,
47 (58.02%) males and 34 (41.97%) females of the mean age
of 65.7 years. The mean history of the disease was 14.5 years. The
median forced expiratory volume in one second (FEV1) was
30.12%. The most common isolated pathogens was Pseudomonas aeruginosa
(n = 36; 38.29%), followed by Haemophilus influenzae (n =
25; 26.59%) and Streptococcus pneumoniae (n = 16; 17.02%). Coinfections
were present in 9 (9.57%) of the patients. The median FEV1
values of 28.67%, 37.23%, and 42.26% were registered in the patients
with Pseudomonas aeruginosa, Haemophilus influenza, and Streptococcus
pneumonia induced infection, respectively. The case fatality rate
(CFR) was 6.2%. Of the deceased, 100% had Pseudomonas aeruginosa-
induced infection. A statistically significant difference in FEV1
values was registered between the patients with and without Pseudomonas
aeruginosa in their sputum finding (p = 0.016). Conclusion.
The most common pathogens in patients with AE-COPD were
Pseudomonas aeruginosa, Haemophilus influenzae, and Streptococcus pneumonia.
The CFR was 6.2%. All (100%) deceased patients had the
infection induced by Pseudomonas aeruginosa.
