Issue: Vojnosanit Pregl 2017; Vol. 74 (No. 1)
Presence of histopathological premalignant lesions and infections caused by high-risk genotypes of human papillomavirus in patients with suspicious cytological and colposcopy results – a prospective study
Authors:
Mileta Golubović, Milena Lopičić, Nataša Terzić, Marija Djurović, Boban Mugoša, Gordana Mijović
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Background/Aim. In patients with premalignant cervical lesions, human papillomavirus (HPV) infection, at any mo-ment, may be spontaneously eliminated, or may persist or transform cervical epithelium from a lower to a higher de-gree. Due to that, it is necessary to wisely select the patients who are at high risk of cancer development. The aim of the study was to establish the interdependence between a suspi-cious Papanicolaou (Pap) test and colposcopy with the in-fection caused by high-risk genotypes of human papillo-mavirus and the presence of premalignant cervical lesions. Methods. This prospective study used cytological, colpo-scopy, real-time polymerase chain reaction (PCR) of high-risk genotypes of human papillomavirus and histopathologi-cal analysis of cervical biopsy specimen. Out of 2,578 fe-male patients sent to cytological analyses in Clinical Center of Montenegro, during 2012, 2013 and 2014, the study in-cluded 80 women who had to submit their biopsy speci-mens due to a suspicious Pap test and atypical colposcopy results. Results. In the group of 80 (3.1%; n = 80/2,578) of the selected female patients with suspicious Pap test and colposcopy, 2/3 or 56 (70%) of them had cervicitis, and 1/3 or 24 (30%) had cervical intraepithelial neoplasia. The most common type in cervical intraepithelial neoplasia was HPV16 in 8 female patients, ie 61.53% out of the number of infected, or 33.33% out of the total number of premalignant lesions. Conclusion. Patients with suspicious Papanicolaou test, colposcopy results and infection which is caused by high-risk HPV infection (HPV 16 in particular) often have premalignant cervical lesions. In these cases, histopathologi-cal confirmation of lesions is mandatory, since it serves as a definitive diagnostic procedure.
